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Title: Aiming for a General Solution to Neglected Tropical Diseases: The case of Leishmaniasis
Presented by: Dr. Timothy K. Beng, CWU Chemistry and Dr. Blaise Dondji, CWU Biology
Leishmaniasis is one of the World’s most problematic diseases in developing countries. Current medicines to treat leishmaniasis have serious side effects, including the state-of-the-art medicine, amphotericin B. The commonly prescribed drugs also suffer from significant parasite resistance problems. In recent years, medicinal chemists have become increasingly keen on escaping flatland in view of exploring three dimensional space for the discovery of new drugs. In this context, chiral nitrogen-containing cyclic compounds such as morpholines and piperidines are valued targets for pharmaceutical companies. In this project, several chiral nitrogen-bearing cyclic compounds are synthesized. The structures of the compounds are then confirmed by routine spectroscopic techniques. Through a collaborative effort, the leishmanicidal activity of these novel compounds against Leishmania major, Leishmania infantum, and Leishmania amazonensis are tested. A detailed structure-activity relationship study is being conducted in hopes of finding the best compound for the treatment of leishmaniasis.
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